Point-of-care evidence-based medicine websites allow physicians to answer clinical queries using recent evidence at the bedside. Despite significant research into the function, usability and effectiveness of these programmes, little attention has been paid to their ethical issues. As many of these sites summarise the literature and provide recommendations, we sought to assess the role of conflicts of interest in two widely used websites: UpToDate and Dynamed. We recorded all conflicts of interest for six articles detailing treatment for the following conditions: (...) erectile dysfunction, fibromyalgia, hypogonadism, psoriasis, rheumatoid arthritis and Crohn's disease. These diseases were chosen as their medical management is either controversial, or they are treated using biological drugs which are mostly available by brand name only. Thus, we hypothesised that the role of conflict of interest would be more significant in these conditions than in an illness treated with generic medications or by strict guidelines. All articles from the UpToDate articles demonstrated a conflict of interest. At times, the editor and author would have a financial relationship with a company whose drug was mentioned within the article. This is in contrast with articles on the Dynamed website, in which no author or editor had a documented conflict. We offer recommendations regarding the role of conflict of interest disclosure in these point-of-care evidence-based medicine websites. (shrink)

We review Side Effects, a 2013 film involving bioethics, pharmaceuticals, and financial conspiracies. After the main character Emily unsuccessfully attempts suicide, she begins receiving care from a psychiatrist, Dr. Banks. Following numerous events, she is placed on a fictional antidepressant, Ablixa, which leads her to suffer from sleepwalking. During an episode of sleepwalking she commits a serious crime. The film poses an interesting dilemma: How responsible would the physician be in this instance? We analyze this question by applying numerous ethical (...) principles. (shrink)

Venturing into novel terrain poses physical risks to a female and her offspring. Females have a greater tendency to avoid physical harm, while males tend to have larger range sizes and often outperform females in navigation-related tasks. Given this backdrop, we expected that females would explore a novel environment with more caution than males, and that more-cautious exploration would negatively affect navigation performance. Participants explored a novel, large-scale, virtual environment in search of five objects, pointed in the direction of each (...) object from the origin, and then navigated back to the objects. We found that females demonstrated more caution while exploring as reflected in the increased amounts of pausing and revisiting of previously traversed locations. In addition, more pausing and revisiting behaviors led to degradation in navigation performance. Finally, individual levels of trait harm avoidance were positively associated with the amount of revisiting behavior during exploration. These findings support the idea that the fitness costs associated with long-distance travel may encourage females to take a more cautious approach to spatial exploration, and that this caution may partially explain the sex differences in navigation performance. (shrink)

While 23andMe aspires to be “the world's trusted source of personal genetic information,” the U.S. Food and Drug Administration (FDA) believes that the company's advertising practices have been anything but trustworthy. Last November, a harshly worded FDA “warning letter” demanded that the direct‐to‐consumer genetic testing company immediately discontinue marketing its unapproved “medical device.” The tussle between 23andMe and the FDA has attracted more attention than a typical disagreement between a company and a government agency. Larry Downes and Paul Nunes identify (...) 23andMe as a “Big Bang Disruption”: an invention that revolutionizes the existing market, foiling both industry incumbents and unprepared regulators. The outcome of the FDA's current review to hold the answer to the million‐dollar question: how will DTC genetic testing be regulated in the future? Ideally, the FDA's regulations should not pose undue burdens on consumers seeking personal genetic information but, rather, help consumers make a transition out of the consumer setting and into the medical setting. (shrink)

Insight problem solving is hindered by automated verbal–conceptual processes. Because mindfulness meditation training aims at “nonconceptual awareness” which involves a reduced influence of habitual verbal–conceptual processes on the interpretation of ongoing experience, mindfulness may facilitate insight problem solving. This hypothesis was examined across two studies . Participants in both studies completed a measure of trait mindfulness and a series of insight and noninsight problems. Further, participants in Study 2 completed measures of positive affect and a mindfulness or control training. The (...) results indicated that trait mindfulness predicts better insight but not noninsight problem solving , this relation is maintained when controlling for positive affect , mindfulness training improves insight but not noninsight problem solving and this improvement is partially mediated by state mindfulness . These findings are the first to document a direct relation between mindfulness and creativity. (shrink)

Zipf famously stated that, if natural language lexicons are structured for efficient communication, the words that are used the most frequently should require the least effort. This observation explains the famous finding that the most frequent words in a language tend to be short. A related prediction is that, even within words of the same length, the most frequent word forms should be the ones that are easiest to produce and understand. Using orthographics as a proxy for phonetics, we test (...) this hypothesis using corpora of 96 languages from Wikipedia. We find that, across a variety of languages and language families and controlling for length, the most frequent forms in a language tend to be more orthographically well‐formed and have more orthographic neighbors than less frequent forms. We interpret this result as evidence that lexicons are structured by language usage pressures to facilitate efficient communication. (shrink)

Although the mapping between form and meaning is often regarded as arbitrary, there are in fact well-known constraints on words which are the result of functional pressures associated with language use and its acquisition. In particular, languages have been shown to encode meaning distinctions in their sound properties, which may be important for language learning. Here, we investigate the relationship between semantic distance and phonological distance in the large-scale structure of the lexicon. We show evidence in 100 languages from a (...) diverse array of language families that more semantically similar word pairs are also more phonologically similar. This suggests that there is an important statistical trend for lexicons to have semantically similar words be phonologically similar as well, possibly for functional reasons associated with language learning. (shrink)

¡Presente! develops a lived theology of nonviolence through an extended case study of the movement to close the School of the Americas (also known as the SOA or WHINSEC). Specifically,it analyzes how the presence of the dead—a presence proclaimed at the annual vigil of the School of the Americas Watch—shapes a distinctive, transnational, nonviolent movement. Kyle B.T. Lambelet argues that such a messianic affirmation need not devolve into violence or sectarianism and, in fact, generates practical reasoning. By developing a (...) messianic political theology in dialogue with the SOA Watch movement, Lambelet's work contributes to Christian ethics as he explores the political implications of the resurrection of the dead. This book contributes to studies of strategic nonviolence and civil resistance by demonstrating how religious and moral dynamics remain an essential part of such struggles. (shrink)

This article proposes potential strategies to address gun violence in communities of color while identifying the harms associated with a policing-centered, criminal legal approach. In addition to highlighting the dangers associated with the United States' current criminal legal tactics to reduce gun violence in these communities, the authors advocate for community-endorsed strategies that give those impacted by this issue the resources to take on gun violence in their own communities. Specifically, they identify, describe, and endorse a series of violence prevention (...) programs that rely on community relations to detect and prevent incidents of gun violence and that view gun violence as a public health rather than criminal legal issue. (shrink)

In this paper I take up the ambivalence we rightly feel toward leaders by examining the relationship between charismatic authority and moral exemplarity. Drawing on the social theory of Max Weber, and in dialogue with a case study of an anti-militarism movement called the SOA (School of Americas) Watch, I demonstrate that through a “politics of sacrifice” leaders synchronize their own stories with those of communally recognized exemplars and act in ways that evidence a solidarity in the suffering of those (...) exemplars thereby generating their charismatic authority. While performing crucial strategic, motivational, and pedagogical roles, this charisma also introduces problematic temptations to authoritarianism that short-circuit the practical reasoning that exemplars supposedly help to form. In the end this leaves our sense of ambivalence intact. What is needed, I argue, are practices of critique that reopen the distance between leader and follower and thus allow the possibility of practical reason. (shrink)

What should we make of the apocalyptic tone taken up by politicians, journalists, scientists, and activists? Some environmental thinkers such as Michael Shellenberger contend that alarming rhetoric distracts us from the technological and governance challenges presented by climate change. In the article, it is argued that retrieving a practical apocalyptic political theology from the Christian tradition can both clarify conceptual contradictions within this discourse as well as offer a practical orientation toward living within ecological endings. Amid the cascade of environmental (...) crises we are living through, apocalyptic practices of renunciation of the world offer a guide and discipline for living in the end. (shrink)

In their article, Nielsen Busch and Mjaaland defend the moral permissibility of cDCD, suggesting that much of the controversy around this donation practice has been the result of a misinterpretatio...

Mobile devices with health apps, direct-to-consumer genetic testing, crowd-sourced information, and other data sources have enabled research by new classes of researchers. Independent researchers, citizen scientists, patient-directed researchers, self-experimenters, and others are not covered by federal research regulations because they are not recipients of federal financial assistance or conducting research in anticipation of a submission to the FDA for approval of a new drug or medical device. This article addresses the difficult policy challenge of promoting the welfare and interests of (...) research participants, as well as the public, in the absence of regulatory requirements and without discouraging independent, innovative scientific inquiry. The article recommends a series of measures, including education, consultation, transparency, self-governance, and regulation to strike the appropriate balance. (shrink)

In order to handle presuppositions in the scope of attitude verbs, the binding theory allows presuppositions triggered in a subject's beliefs to be bound at the matrix level; and it allows presuppositions triggered in non-doxastic attitudes to be bound in the subject's beliefs (Geurts, 1999; Maier, 2015). However, we argue that this leads to serious overgeneration, for example it predicts that the unacceptable `Sue will come to the party, but Bill is sure that she won't and that only Sue will (...) come to the party' should be equivalent to the acceptable `Sue will come to the party, but Bill is sure that nobody will come to the party'. This is because the presupposition triggered by `only Sue will come to the party' should be able to be bound at the matrix level. We discuss some responses to this problem, but argue that they all have shortcomings. (shrink)

Harry Chalmers argues that monogamy involves restricting one’s partner’s access to goods in a morally troubling way that is analogous to an agreement between partners to have no additional friends. Chalmers finds the traditional defenses of monogamy wanting, since they would also justify a friendship-restricting agreement. I show why three traditional defenses of monogamy hold up quite well and why they don’t, for the most part, also justify friendship-restricting agreements. In many cases, monogamy can be justified on grounds of practicality, (...) specialness, or jealousy. (shrink)

Beginning in the 20th century, scientific research came to be dominated by a growing class of credentialed, professional scientists who overwhelmingly displaced the learned amateurs of an earlier time. By the end of the century, however, the exclusive realm of professional scientists conducting research was joined, to a degree, by “citizen scientists.” The term originally encompassed non-professionals assisting professional scientists by contributing observations and measurements to ongoing research enterprises. These collaborations were especially common in the environmental sciences, where citizen scientists (...) participated in counting wildlife and measuring environmental conditions. Later, patient groups began to play a more active role in supporting clinical trials and collecting health records from affected individuals. (shrink)

In this paper, we propose a novel account of desire reports, i.e. sentences of the form 'S wants p'. Our theory is partly motivated by Phillips-Brown's (2021) observation that subjects can desire things even if those things aren't best by the subject's lights. That is, being best isn't necessary for being desired. We compare our proposal to existing theories, and show that it provides a neat account of the central phenomenon.

Unlike first-person Moorean sentences, it’s not always awkward to assert, “p, but you don’t know that p.” This can seem puzzling: after all, one can never get one’s audience to know the asserted content by speaking thus. Nevertheless, such assertions can be conversationally useful, for instance, by helping speaker and addressee agree on where to disagree. I will argue that such assertions also make trouble for the growing family of views about the norm of assertion that what licenses proper assertion (...) is not the initiating epistemic position of the speaker but the resulting epistemic position of the audience. (shrink)

The nearly omnipotent character known only as “Q” dramatically enters the Star Trek universe when he puts all humanity in the person of Captain Jean‐Luc Picard, on trial in the first episode of TNG. Acting as self‐professed prosecutor, judge, and jury, Q promises Picard an “absolutely equitable” trial, only to coerce Picard into pleading “guilty” by threatening to kill his crew. Q could be like the “Leviathan” of Thomas Hobbes (1588‐1679), an absolute sovereign who has the power to keep people (...) from warring with each other, but who can't be held accountable or subject to any civil law in the use of that power. Enlisting Hobbes and Locke, this chapter examines the motives behind Q's enigmatic actions and sees what Q, deep down, might believe about justice. Hobbes begins with a basic right of nature that all people possess: our liberty to ensure the preservation of our own life. (shrink)

Academic dishonesty, including cheating and plagiarism, is on the rise in colleges, particularly among engineering students. While students decide to engage in these behaviors for many different reasons, academic integrity training can help improve their understanding of ethical decision making. The two studies outlined in this paper assess the effectiveness of an online module in increasing academic integrity among first semester engineering students. Study 1 tested the effectiveness of an academic honesty tutorial by using a between groups design with a (...) Time 1- and Time 2-test. An academic honesty quiz assessed participants’ knowledge at both time points. Study 2, which incorporated an improved version of the module and quiz, utilized a between groups design with three assessment time points. The additional Time 3-test allowed researchers to test for retention of information. Results were analyzed using ANCOVA and t tests. In Study 1, the experimental group exhibited significant improvement on the plagiarism items, but not the total score. However, at Time 2 there was no significant difference between groups after controlling for Time 1 scores. In Study 2, between- and within-group analyses suggest there was a significant improvement in total scores, but not plagiarism scores, after exposure to the tutorial. Overall, the academic integrity module impacted participants as evidenced by changes in total score and on specific plagiarism items. Although future implementation of the tutorial and quiz would benefit from modifications to reduce ceiling effects and improve assessment of knowledge, the results suggest such tutorial may be one valuable element in a systems approach to improving the academic integrity of engineering students. (shrink)

Democritus’ atomism aims to respond to threats of Parmenidean monism. In so doing, it deploys a familiar epistemological distinction between what is known by the senses and what is known by the mind. This turns out to be a risky strategy, however, leading to inadvertent skepticism with only diffuse and contrary ethical implications. Vasubandhu’s more explicitly metaphysical atomism, by contrast, relies on a different principle to get to its results, and aims to address different concerns. It leaves us with a (...) view that positively implies a concrete mode of practical engagement, and resources for a critical stance. Even if certain atoms end up proven incoherent, there is no danger of slipping into the morally fatal indifference of inadvertent skepticism. For the ethical implications, it matters how one arrives at one’s atomism. (shrink)

Many philosophers think that we can identify, e.g., a weather expert by checking if she has a track record of making accurate weather predictions but that there isn’t an analogous way for laypeople to verify the judgement of a putative moral expert. The weather is an independent check for weather expertise but there is no independent check for moral expertise, and the only way for laypeople to identify moral experts is to engage in first-order moral reasoning of one’s own. But (...) if one can do that, one would not need to rely on a moral expert in the first place. This paper provides an account of Feedback as an independent check for moral expertise in the form of certain positive and negative changes in the lives of advisees after they started acting in accordance with an advisor’s advice whilst nothing else of significance changed in their lives in that period. Given our folk background theories, and some specific information about the advisee’s situation, Feedback suggests that the advisor’s advice was correct. Laypeople would identify moral experts by inferring that the best explanation of the correctness of the advisor’s advice in a high proportion of cases in which she dispensed advice is that the advisor had moral knowledge. Identifying moral experts in this way involves the use of some moral reasoning of one’s own but it is too elementary to make moral experts redundant. (shrink)

Many philosophers think that we can identify, e.g., a weather expert by checking if she has a track record of making accurate weather predictions but that there isn’t an analogous way for laypeople to verify the judgement of a putative moral expert. The weather is an independent check for weather expertise but there is no independent check for moral expertise, and the only way for laypeople to identify moral experts is to engage in first-order moral reasoning of one’s own. But (...) if one can do that, one would not need to rely on a moral expert in the first place. This paper provides an account of Feedback as an independent check for moral expertise in the form of certain positive and negative changes in the lives of advisees after they started acting in accordance with an advisor’s advice whilst nothing else of significance changed in their lives in that period. Given our folk background theories, and some specific information about the advisee’s situation, Feedback suggests that the advisor’s advice was correct. Laypeople would identify moral experts by inferring that the best explanation of the correctness of the advisor’s advice in a high proportion of cases in which she dispensed advice is that the advisor had moral knowledge. Identifying moral experts in this way involves the use of some moral reasoning of one’s own but it is too elementary to make moral experts redundant. (shrink)

In 2010, pitcher Armando Galarraga was denied a perfect game when umpire Jim Joyce called Jason Donald safe at first with two outs in the bottom of the 9th. In the numerous media discussions that followed, Joyce’s ‘blown’ call was commonly referred to as ‘mistaken’, ‘wrong’, or otherwise erroneous. However, this use of language makes some not uncontroversial ontological assumptions. It claims that the fact that a runner is safe or out has nothing to do with the ruling of the (...) umpire himself, but rather with some state of the universe that does not depend on the umpire for its existence. In this paper, I recast the problem as a version of Plato’s Euthyphro Dilemma and argue that the view implied by the above assertions is actually misguided. Instead, I hope to show that an alternative view – what I call ‘restricted umpire voluntarism’ – is actually more in line with the spirit of the game of baseball and is not as counterintuitive as it may appear.. (shrink)

According to the doctrine of infallibility, one is permitted to believe p if one knows that necessarily, one would be right if one believed that p. This plausible principle—made famous in Descartes’ cogito—is false. There are some self-fulfilling, higher-order propositions one can’t be wrong about but shouldn’t believe anyway: believing them would immediately make one's overall doxastic state worse.

Don't pray for war -- Is democracy worth it? -- Taking speech seriously -- In recognition of limits -- The limits of politics.

Baseball is an exceptionally superstitious sport. But what are we to say about the rationality of such superstitious behavior? On the one hand, we can trace much of the superstitious behavior we see in baseball to a type of irrational belief. But how deep does this supposed irrationality run? It appears that superstitions may occupy various places on the spectrum of irrationality — from motivated ignorance to self-deception to psychological compulsion —depending on the type of superstitious belief at work and (...) on the means of formation and/or maintenance of that belief. In this paper, I first examine the various types of superstitions we find in baseball culture, in an attempt to see what these different kinds of superstitions might have in common. I then lay out a working definition of superstition within a baseball context by examining the general psychology underlying such behavior, in an attempt to ascertain the possible causal and/or motivational reasons for the acquisition of superstitious beliefs and practices in sports like baseball. Finally, I argue that, in addition to superstitions acquired merely via the workings of a type of biasing mechanism, there also appear to be genuine cases of superstition acquisition and maintenance, in which the agent may be said to be actively engaged. I claim that in at least some cases of superstitious belief, it is possible that agents are employing an awareness of their own rational epistemic standards to allow themselves to believe and act irrationally, and that the result of such “pseudo-rational” behavior is perhaps a form of self-deceptive superstitious belief. (shrink)

BackgroundThe increased risk of developing attention-deficit hyperactivity disorder (ADHD) in extremely preterm infants is well-documented. Better understanding of perinatal risk factors, particularly those that are modifiable, can inform prevention efforts.MethodsWe examined data from the Extremely Low Gestational Age Newborns (ELGAN) Study. Participants were screened for ADHD at age 10 with the Child Symptom Inventory-4 (N = 734) and assessed at age 15 with a structured diagnostic interview (MINI-KID) to evaluate for the diagnosis of ADHD (N = 575). We studied associations (...) of pre-pregnancy maternal body mass index (BMI), pregestational and/or gestational diabetes, maternal smoking during pregnancy (MSDP), and hypertensive disorders of pregnancy (HDP) with 10-year and 15-year ADHD outcomes. Relative risks were calculated using Poisson regression models with robust error variance, adjusted for maternal age, maternal educational status, use of food stamps, public insurance status, marital status at birth, and family history of ADHD. We defined ADHD as a positive screen on the CSI-4 at age 10 and/or meeting DSM-5 criteria at age 15 on the MINI-KID. We evaluated the robustness of the associations to broadening or restricting the definition of ADHD. We limited the analysis to individuals with IQ ≥ 70 to decrease confounding by cognitive functioning. We evaluated interactions between maternal BMI and diabetes status. We assessed for mediation of risk increase by alterations in inflammatory or neurotrophic protein levels in the first week of life.ResultsElevated maternal BMI and maternal diabetes were each associated with a 55–65% increase in risk of ADHD, with evidence of both additive and multiplicative interactions between the two exposures. MSDP and HDP were not associated with the risk of ADHD outcomes. There was some evidence for association of ADHD outcomes with high levels of inflammatory proteins or moderate levels of neurotrophic proteins, but there was no evidence that these mediated the risk associated with maternal BMI or diabetes.ConclusionContrary to previous population-based studies, MSDP and HDP did not predict ADHD outcomes in this extremely preterm cohort, but elevated maternal pre-pregnancy BMI, maternal diabetes, and perinatal inflammatory markers were associated with increased risk of ADHD at age 10 and/or 15, with positive interaction between pre-pregnancy BMI and maternal diabetes. (shrink)

Although Hurricane Katrina precipitated considerable reflection across various media, a practice crucial to our capacities to apprehend and interpret the disaster has not yet been analyzed as such. I call this practice generative assembly. I don’t mean the events of emergency and political gathering that took place in response to the massive storm and fatal, preventable levee failures—although I will propose connections between different forms of assembly. Instead I mean a kind of documentary practice. That practice, which can be undertaken (...) individually or in collaboration, and sometimes at anonymous remove, involves the work of assembling records and signifiers related to the disaster into particular kinds of media artifacts. Those artifacts— which take shape in formats as varied as comics, photobooks, paintings, films, exhibitions, and multithousand-item online archives—characteristically maintain the active appearance and interactive potential of selection and arrangement. In exhibiting such qualities, or so I will argue, these assembly-based artifacts support various articulable and often highly effective kinds of generativity. And thus, I will further suggest, these artifacts can constitute especially powerful means of intervening in prevailing conditions of representation and remembrance around events of environmental and social violence. Crucially, those material legacies of generative assembly can also fall short, fail, and deceive, and this is especially true of those assemblies that take digital forms. It is my contention, however, that we would be misguided if we thus entirely dismissed such assemblies or if we refused their potential for dissident reuse or generative reassembly. (shrink)

Some writers, such as John Fischer and Michael McKenna, have recently claimed that an agent can be morally responsible for a wrong action and yet not be blameworthy for that action. A careful examination of the claim, however, suggests two readings. On one reading, there are further conditions on blameworthiness beyond freely and wittingly doing wrong. On another innocuous reading, there are no such further conditions. Despite Fischer and McKenna’s attempts to offer further conditions on blameworthiness in addition to responsibility (...) for wrongdoing, I argue that only the innocuous reading is plausible. Once we distinguish between blame being deserved and blame being all-things-considered appropriate, we need not appeal to further conditions on blameworthiness. This discussion has important upshots regarding how compatibilists respond to certain manipulation arguments and how proponents of derived responsibility respond to criticism that agents are responsible even for outcomes that are not reasonably foreseeable. (shrink)

Despite recent controversies surrounding the principle that knowledge entails truth (KT), this paper aims to prove that the principle is true. It offers a proof of (KT) in the following sense. It advances a deductively valid argument for (KT), whose premises are, by most lights, obviously true. Moreover, each premise is buttressed by at least two supporting arguments. And finally, all premises and supporting arguments can be rationally accepted by people who don’t already accept (KT).

Where does entitlement to trust come from? When we trust someone to φ, do we need to have reason to trust them to φ or do we start out entitled to trust them to φ by default? Reductivists think that entitlement to trust always “reduces to” or is explained by the reasons that agents have to trust others. In contrast, anti-reductivists think that, in a broad range of circumstances, we just have entitlement to trust. even if we don’t have positive (...) reasons to do so. In this paper, we argue for a version of anti-reductivism. Roughly, we argue that we have default entitlement to trust someone to φ so long as there is an operative norm that requires S to φ. At least in such circumstances (and absent defeaters), we don’t need any positive reasons to trust S to φ. (shrink)

Don’t Look Up is a 2021 Netflix original film about two astronomers who discover a 9-kilometer “planet killer” comet on a collision course with Earth. The way humanity responds to this threat – which is less than ideal, given that the movie ends with humanity’s destruction – is supposed to be an allegory for how humanity is dealing with the real-world threat of climate change. Consequently, we argue, the movie is an argument that presents the viewer with a moral imperative: (...) Do all that you can to prevent climate change. But does the argument work? To answer this question, we look at criticism of the movie, decipher its messages, examine the aptness of its analogy, and use the philosophy of Plato, Kant, and Peter Singer to explain exactly what kind of argument the film is. In the end, we conclude that, while most (although not all) criticisms of the film fall flat – it doesn’t really matter. Given that the moral imperative presented by the movie is undeniable, the only appropriate response to the film is an unrelenting effort to fulfill our duty to stop climate change. (shrink)